Structured Summary
Abstract
An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A.
Chemical Identity
Chemical Information
- Molecular Formula
- C37H48N4O5
- Molecular Weight
- 628.8 g/mol
- CAS Registry No.
- 192725-17-0
- IUPAC Name
- (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
- InChIKey
- KJHKTHWMRKYKJE-SUGCFTRWSA-N
- SMILES
- CC1=C(C(=CC=C1)C)OCC(=O)N[C@@H](CC2=CC=CC=C2)[C@H](C[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)N4CCCNC4=O)O
- MeSH Unique ID
- D061466
- Source
- PubChem CID 92727
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
7 entry terms
- N-(4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pydrimidineacetamide
- A-157378.0
- ABT 378
- ABT-378
- A 157378.0
- A157378.0
- ABT378
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2012
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Lopinavir. Medical Subject Headings (MeSH). 2026. Unique ID D061466. http://id.nlm.nih.gov/mesh/2026/D061466
- Lopinavir. In: Wikipedia. https://en.wikipedia.org/wiki/Lopinavir
- Lopinavir. In: Wikidata. https://www.wikidata.org/wiki/Q422585
- Lopinavir. In: PubChem Compound. CID 92727. https://pubchem.ncbi.nlm.nih.gov/compound/92727