Phenomena and Processes

Long-Term Synaptic Depression

A persistent activity-dependent decrease in synaptic efficacy between NEURONS. It typically occurs following repeated low-frequency afferent stimulation, but it can be induced by other methods. Long-term depression appears to play a role in MEMORY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A persistent activity-dependent decrease in synaptic efficacy between NEURONS. It typically occurs following repeated low-frequency afferent stimulation, but it can be induced by other methods. Long-term depression appears to play a role in MEMORY.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

25 entry terms
  • Long-Term Depression, Neurophysiologic
  • Long-Term Depression, Neurophysiological
  • Long-Term Depression, Physiologic
  • Long-Term Depression, Physiological
  • Depression, Neurophysiological Long-Term
  • Depression, Physiological Long-Term
  • Depressions, Neurophysiological Long-Term
  • Depressions, Physiological Long-Term
  • Long Term Depression, Neurophysiologic
  • Long Term Depression, Neurophysiological
  • Long Term Depression, Physiologic
  • Long Term Depression, Physiological
  • Long Term Synaptic Depression
  • Long-Term Depressions, Neurophysiological
  • Long-Term Depressions, Physiological
  • Neurophysiologic Long-Term Depression
  • Neurophysiological Long-Term Depression
  • Neurophysiological Long-Term Depressions
  • Physiologic Long-Term Depression
  • Physiological Long-Term Depression
  • Physiological Long-Term Depressions
  • Synaptic Depression, Long-Term
  • Depotentiation
  • Homosynaptic Depression
  • Depression, Homosynaptic

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

Indexing Annotation

note category: do not confuse with clinical DEPRESSION or DEPRESSIVE DISORDERS

MeSH Record

History Note

2008 (2003)

MeSH Record

Previous Indexing

  • Neuronal Plasticity (1985-2002)

MeSH Hierarchy

Tree Number

  1. G11.561.638w.355w

MeSH Record

NLM Classification

WL 102

AMA Style

References

  1. National Library of Medicine. Long-Term Synaptic Depression. Medical Subject Headings (MeSH). 2026. Unique ID D036881. http://id.nlm.nih.gov/mesh/2026/D036881
  2. Long-Term Synaptic Depression. In: Wikipedia. https://en.wikipedia.org/wiki/Long-term_depression
  3. Long-Term Synaptic Depression. In: Wikidata. https://www.wikidata.org/wiki/Q1517140