Structured Summary
Abstract
A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE.
Chemical Identity
Chemical Information
- Molecular Formula
- C26H27ClN2O
- Molecular Weight
- 419.0 g/mol
- CAS Registry No.
- 23047-25-8
- IUPAC Name
- 1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone
- InChIKey
- SAPNXPWPAUFAJU-UHFFFAOYSA-N
- SMILES
- CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl
- MeSH Unique ID
- D008127
- Source
- PubChem CID 3947
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
9 entry terms
- Lopramine
- Deftan
- Feprapax
- Gamanil
- Gamonil
- Leo 640
- Lofepramine Hydrochloride
- Lomont
- Hydrochloride, Lofepramine
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
91(79); was see under DIBENZAZEPINES 1979-90
MeSH Record
Previous Indexing
- Dibenzazepines (1969-1978)
MeSH Hierarchy
Tree Number
MeSH Record
NLM Classification
QV 77.5
AMA Style
References
- National Library of Medicine. Lofepramine. Medical Subject Headings (MeSH). 2026. Unique ID D008127. http://id.nlm.nih.gov/mesh/2026/D008127
- Lofepramine. In: Wikipedia. https://en.wikipedia.org/wiki/Lofepramine
- Lofepramine. In: Wikidata. https://www.wikidata.org/wiki/Q368941
- Lofepramine. In: PubChem Compound. CID 3947. https://pubchem.ncbi.nlm.nih.gov/compound/3947