Chemicals and Drugs

Levallorphan

An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)

Chemical Identity

Chemical Information

Molecular Formula
C19H25NO
Molecular Weight
283.4 g/mol
CAS Registry No.
152-02-3
IUPAC Name
(1R,9R,10R)-17-prop-2-enyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
InChIKey
OZYUPQUCAUTOBP-QXAKKESOSA-N
SMILES
C=CCN1CC[C@]23CCCC[C@H]2[C@H]1CC4=C3C=C(C=C4)O
MeSH Unique ID
D007977
Source
PubChem CID 5359371

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • Naloxiphan
  • Lorfan

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

65; was see under NARCOTIC ANTAGONISTS 1963-64

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.577.249.413w
  2. D03w.605.497.429w
  3. D03w.633.400.686.429w
  4. D04w.615w.723w.795.413w

AMA Style

References

  1. National Library of Medicine. Levallorphan. Medical Subject Headings (MeSH). 2026. Unique ID D007977. http://id.nlm.nih.gov/mesh/2026/D007977
  2. Levallorphan. In: Wikipedia. https://en.wikipedia.org/wiki/Levallorphan
  3. Levallorphan. In: Wikidata. https://www.wikidata.org/wiki/Q6534827
  4. Levallorphan. In: PubChem Compound. CID 5359371. https://pubchem.ncbi.nlm.nih.gov/compound/5359371