Chemicals and Drugs

Leukotriene E4

A biologically active principle of SRS-A that is formed from LEUKOTRIENE D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A biologically active principle of SRS-A that is formed from LEUKOTRIENE D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990)

Chemical Identity

Chemical Information

Molecular Formula
C23H37NO5S
Molecular Weight
439.6 g/mol
CAS Registry No.
75715-89-8
IUPAC Name
(5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
InChIKey
OTZRAYGBFWZKMX-FRFVZSDQSA-N
SMILES
CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N
MeSH Unique ID
D017999
Source
PubChem CID 5280879

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

5 entry terms
  • LTE4
  • Leukotriene E-4
  • Leukotriene E 4
  • Leukotriene E
  • Leukotrienes E

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

94; was LEUKOTRIENE E (NM) 1980-93

MeSH Record

Previous Indexing

  • Arachidonic Acids (1980-1982)
  • SRS-A/analogs & derivatives (1983-1993)

MeSH Hierarchy

Tree Numbers

  1. D10w.251w.355w.255w.100.450w.855w.470w
  2. D10w.251w.355w.310w.166.887w.855w.470w
  3. D23.469.050w.175w.450w.725w.425w

AMA Style

References

  1. National Library of Medicine. Leukotriene E4. Medical Subject Headings (MeSH). 2026. Unique ID D017999. http://id.nlm.nih.gov/mesh/2026/D017999
  2. Leukotriene E4. In: Wikipedia. https://en.wikipedia.org/wiki/Leukotriene_E4
  3. Leukotriene E4. In: Wikidata. https://www.wikidata.org/wiki/Q2705859
  4. Leukotriene E4. In: PubChem Compound. CID 5280879. https://pubchem.ncbi.nlm.nih.gov/compound/5280879