Chemicals and Drugs

Leukotriene D4

One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)

Chemical Identity

Chemical Information

Molecular Formula
C25H40N2O6S
Molecular Weight
496.7 g/mol
CAS Registry No.
73836-78-9
IUPAC Name
(5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
InChIKey
YEESKJGWJFYOOK-IJHYULJSSA-N
SMILES
CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)N
MeSH Unique ID
D017998
Source
PubChem CID 5280878

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

5 entry terms
  • LTD4
  • Leukotriene D-4
  • Leukotriene D 4
  • Leukotriene D
  • Leukotrienes D

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

94; was see SRS-A 1983-93; LEUKOTRIENES D was see SRS-A 1983-93

MeSH Record

Previous Indexing

  • SRS-A (1982-1993)

MeSH Hierarchy

Tree Numbers

  1. D10w.251w.355w.255w.100.450w.855w.461w
  2. D10w.251w.355w.310w.166.887w.855w.461w
  3. D23.469.050w.175w.450w.725w.415w

AMA Style

References

  1. National Library of Medicine. Leukotriene D4. Medical Subject Headings (MeSH). 2026. Unique ID D017998. http://id.nlm.nih.gov/mesh/2026/D017998
  2. Leukotriene D4. In: Wikipedia. https://en.wikipedia.org/wiki/Leukotriene_D4
  3. Leukotriene D4. In: Wikidata. https://www.wikidata.org/wiki/Q647917
  4. Leukotriene D4. In: PubChem Compound. CID 5280878. https://pubchem.ncbi.nlm.nih.gov/compound/5280878