Chemicals and Drugs

Leukotriene C4

The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)

Chemical Identity

Chemical Information

Molecular Formula
C30H47N3O9S
Molecular Weight
625.8 g/mol
CAS Registry No.
72025-60-6
IUPAC Name
(5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
InChIKey
GWNVDXQDILPJIG-NXOLIXFESA-N
SMILES
CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N
MeSH Unique ID
D017997
Source
PubChem CID 5280493

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

8 entry terms
  • LTC4
  • Leukotriene C-4
  • Leukotriene C 4
  • Leukotriene C
  • Leukotriene C-1
  • Leukotriene C1
  • Leukotrienes C
  • Leukotriene C 1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

94; was see SRS-A 1983-93; LEUKOTRIENE C1 & LEUKOTRIENES C were see SRS-A 1983-93

MeSH Record

Previous Indexing

  • SRS-A (1981-1993)

MeSH Hierarchy

Tree Numbers

  1. D10w.251w.355w.255w.100.450w.855w.455w
  2. D10w.251w.355w.310w.166.887w.855w.455w
  3. D23.469.050w.175w.450w.725w.400w

AMA Style

References

  1. National Library of Medicine. Leukotriene C4. Medical Subject Headings (MeSH). 2026. Unique ID D017997. http://id.nlm.nih.gov/mesh/2026/D017997
  2. Leukotriene C4. In: Wikipedia. https://en.wikipedia.org/wiki/Leukotriene_C4
  3. Leukotriene C4. In: Wikidata. https://www.wikidata.org/wiki/Q2704310
  4. Leukotriene C4. In: PubChem Compound. CID 5280493. https://pubchem.ncbi.nlm.nih.gov/compound/5280493