Chemicals and Drugs

Leukotriene B4

The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)

Chemical Identity

Chemical Information

Molecular Formula
C20H32O4
Molecular Weight
336.5 g/mol
CAS Registry No.
71160-24-2
IUPAC Name
(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
InChIKey
VNYSSYRCGWBHLG-AMOLWHMGSA-N
SMILES
CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O
MeSH Unique ID
D007975
Source
PubChem CID 5280492

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

10 entry terms
  • LTB4
  • Leukotriene B-4
  • B-4, Leukotriene
  • Leukotriene B 4
  • 5,12-HETE
  • 5,12-diHETE
  • Leukotriene B
  • Leukotrienes B
  • 5,12 HETE
  • 5,12 diHETE

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

94; was LEUKOTRIENES B 1983-93; LEUKOTRIENE B4 was see LEUKOTRIENES B 1983-93

MeSH Record

Previous Indexing

  • Arachidonic Acids (1967-1982)

MeSH Hierarchy

Tree Numbers

  1. D10w.251w.355w.255w.100.450w.411w
  2. D10w.251w.355w.310w.166.887w.411w
  3. D23.469.050w.175w.450w.415w

MeSH Record

NLM Classification

QU 90

AMA Style

References

  1. National Library of Medicine. Leukotriene B4. Medical Subject Headings (MeSH). 2026. Unique ID D007975. http://id.nlm.nih.gov/mesh/2026/D007975
  2. Leukotriene B4. In: Wikipedia. https://en.wikipedia.org/wiki/Leukotriene_B4
  3. Leukotriene B4. In: Wikidata. https://www.wikidata.org/wiki/Q2704449
  4. Leukotriene B4. In: PubChem Compound. CID 5280492. https://pubchem.ncbi.nlm.nih.gov/compound/5280492