Phenomena and Processes

Leukocyte Rolling

Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas, Cellular and Molecular Immunology, 3rd ed)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas, Cellular and Molecular Immunology, 3rd ed)

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Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • Leucocyte Rolling
  • Rolling, Leucocyte
  • Rolling, Leukocyte

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2003

MeSH Record

Previous Indexing

  • Cell Adhesion (1991-2002)
  • Cell Movement (1991-2002)

MeSH Hierarchy

Tree Number

  1. G04.198.424w.233.500

AMA Style

References

  1. National Library of Medicine. Leukocyte Rolling. Medical Subject Headings (MeSH). 2026. Unique ID D036904. http://id.nlm.nih.gov/mesh/2026/D036904
  2. Leukocyte Rolling. In: Wikidata. https://www.wikidata.org/wiki/Q71228927