Chemicals and Drugs

Leukocyte L1 Antigen Complex

A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.

MeSH Record

Classification

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MeSH Record

Synonyms

14 entry terms
  • 27E10 Antigen
  • Calcium-Binding Myeloid Protein P8,14
  • Calgranulin
  • Calprotectin
  • L1 Antigen
  • Leukocyte L1 Protein
  • Migratory Inhibitory Factor-Related Protein MRP
  • Myelomonocytic Antigen L1
  • Antigen L1, Myelomonocytic
  • Antigen, 27E10
  • Antigen, L1
  • Calcium Binding Myeloid Protein P8,14
  • L1 Protein, Leukocyte
  • Migratory Inhibitory Factor Related Protein MRP

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1984-2002

MeSH Record

Previous Indexing

  • Antigens, Surface (1984-1991)
  • Cell Adhesion Molecules, Neuronal (1992-1995)
  • Membrane Glycoproteins (1984-2002)
  • Neural Cell Adhesion Molecules (1996-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.125w.750w.500w
  2. D12.776w.631w.658w.750w
  3. D23.050w.301.562w

AMA Style

References

  1. National Library of Medicine. Leukocyte L1 Antigen Complex. Medical Subject Headings (MeSH). 2026. Unique ID D039841. http://id.nlm.nih.gov/mesh/2026/D039841
  2. Leukocyte L1 Antigen Complex. In: Wikipedia. https://en.wikipedia.org/wiki/Calprotectin
  3. Leukocyte L1 Antigen Complex. In: Wikidata. https://www.wikidata.org/wiki/Q22328664