Chemicals and Drugs

Leukocyte Common Antigens

High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

30 entry terms
  • Antigens, CD45
  • CD45 Antigen
  • CD45 Antigens
  • L-CA Antigens
  • Leukocyte Common Antigen
  • Protein Tyrosine Phosphatase, Receptor Type, C
  • T200 Antigens
  • Antigen, CD45
  • Antigen, Leukocyte Common
  • Antigens, L-CA
  • Antigens, Leukocyte Common
  • Antigens, T200
  • L CA Antigens
  • 2H4 Antigens
  • B220 Antigen
  • B220 Antigens
  • CD45R Antigens
  • CD45R0 Antigens
  • CD45RA Antigens
  • CD45RB Antigens
  • CD45RCAntigens
  • CD45RO Antigens
  • Antigen, B220
  • Antigens, 2H4
  • Antigens, B220
  • Antigens, CD45R
  • Antigens, CD45R0
  • Antigens, CD45RA
  • Antigens, CD45RB
  • Antigens, CD45RO

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1993); for RT7 use HISTOCOMPATIBILITY ANTIGENS RT 1983-92; for B220 ANTIGEN use ANTIGENS, CD45 1990-95

MeSH Record

Previous Indexing

  • Antigens, CD (1989-1992)
  • Antigens, Differentiation (1984-1991)
  • Histocompatibility Antigens (1984-1992)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.650w.775w.400.100.500
  2. D12.776w.476.564w.400.100.500
  3. D12.776w.543w.733.937.500

AMA Style

References

  1. National Library of Medicine. Leukocyte Common Antigens. Medical Subject Headings (MeSH). 2026. Unique ID D017493. http://id.nlm.nih.gov/mesh/2026/D017493
  2. Leukocyte Common Antigens. In: Wikidata. https://www.wikidata.org/wiki/Q24776550