Chemicals and Drugs

Leucovorin

The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.

Chemical Identity

Chemical Information

Molecular Formula
C20H23N7O7
Molecular Weight
473.4 g/mol
CAS Registry No.
58-05-9
IUPAC Name
(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
InChIKey
VVIAGPKUTFNRDU-ABLWVSNPSA-N
SMILES
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
MeSH Unique ID
D002955
Source
PubChem CID 135403648

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

26 entry terms
  • Folinic Acid
  • Folinic Acid-SF
  • Leukovorin
  • Leukovorum
  • Acid, Folinic
  • Folinic Acid SF
  • 5-Formyltetrahydrofolate
  • 5-Formyltetrahydropteroylglutamate
  • Calcium Folinate
  • Calcium Leucovorin
  • Citrovorum Factor
  • Leucovorin, (D)-Isomer
  • Leucovorin, (DL)-Isomer
  • Leucovorin, (R)-Isomer
  • Leucovorin, Calcium (1:1) Salt
  • Leucovorin, Calcium (1:1) Salt, (DL)-Isomer
  • Leucovorin, Calcium (1:1) Salt, Pentahydrate
  • Leucovorin, Monosodium Salt
  • N(5)-Formyltetrahydrofolate
  • Wellcovorin
  • 5 Formyltetrahydrofolate
  • 5 Formyltetrahydropteroylglutamate
  • Factor, Citrovorum
  • Folinate, Calcium
  • Leucovorin, Calcium
  • Monosodium Salt Leucovorin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

deficiency: coordinate LEUCOVORIN /defic (IM) with FOLIC ACID DEFICIENCY (IM)

MeSH Record

History Note

90; was CITROVORUM FACTOR 1964-89

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Leucovorin. Medical Subject Headings (MeSH). 2026. Unique ID D002955. http://id.nlm.nih.gov/mesh/2026/D002955
  2. Leucovorin. In: Wikipedia. https://en.wikipedia.org/wiki/Folinic_acid
  3. Leucovorin. In: Wikidata. https://www.wikidata.org/wiki/Q45435667
  4. Leucovorin. In: PubChem Compound. CID 135403648. https://pubchem.ncbi.nlm.nih.gov/compound/135403648