Phenomena and Processes

Leucine Zippers

DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the zipper region). The DNA-binding residues are located in the bifurcated region of the Y.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the zipper region). The DNA-binding residues are located in the bifurcated region of the Y.

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Synonyms

3 entry terms
  • Leucine Zipper
  • Zipper, Leucine
  • Zippers, Leucine

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Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

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History Note

91

MeSH Record

Previous Indexing

  • Amino Acid Sequence (1989-1990)
  • DNA-Binding Proteins (1989-1990)
  • Molecular Sequence Data (1989-1990)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.500.520w

AMA Style

References

  1. National Library of Medicine. Leucine Zippers. Medical Subject Headings (MeSH). 2026. Unique ID D016350. http://id.nlm.nih.gov/mesh/2026/D016350
  2. Leucine Zippers. In: Wikipedia. https://en.wikipedia.org/wiki/Leucine_zipper
  3. Leucine Zippers. In: Wikidata. https://www.wikidata.org/wiki/Q2565229