Chemicals and Drugs

Letrozole

A triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to ANASTROZOLE. It is used in the treatment of metastatic or locally advanced breast cancer in postmenopausal women.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to ANASTROZOLE. It is used in the treatment of metastatic or locally advanced breast cancer in postmenopausal women.

Chemical Identity

Chemical Information

Molecular Formula
C17H11N5
Molecular Weight
285.30 g/mol
CAS Registry No.
112809-51-5
IUPAC Name
4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
InChIKey
HPJKCIUCZWXJDR-UHFFFAOYSA-N
SMILES
C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3
MeSH Unique ID
D000077289
Source
PubChem CID 3902

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • 4,4'-(1H-1,2,4-triazol-1-yl-methylene)-bis(benzonitrile)
  • CGS 20267
  • CGS-20267
  • Femara
  • Fémara
  • CGS20267

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1991)

MeSH Hierarchy

Tree Numbers

  1. D02w.626w.300w
  2. D03w.383.129w.799w.638w

AMA Style

References

  1. National Library of Medicine. Letrozole. Medical Subject Headings (MeSH). 2026. Unique ID D000077289. http://id.nlm.nih.gov/mesh/2026/D000077289
  2. Letrozole. In: Wikipedia. https://en.wikipedia.org/wiki/Letrozole
  3. Letrozole. In: Wikidata. https://www.wikidata.org/wiki/Q194974
  4. Letrozole. In: PubChem Compound. CID 3902. https://pubchem.ncbi.nlm.nih.gov/compound/3902