Diseases

Large Granular Lymphocytic Leukemia

A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

39 entry terms
  • Aggressive NK Cell Leukemia
  • Aggressive Natural Killer Cell Leukemia
  • LGL Leukemia
  • Large Granular Lymphocyte Leukemia
  • Leukemia, LGL
  • Leukemia, Large Granular Lymphocytic
  • Leukemia, Lymphocytic, Large Granular
  • Lymphoproliferative Disease of Granular Lymphocytes
  • Lymphoproliferative Disease of Large Granular Lymphocytes
  • LGL Leukemias
  • Leukemias, LGL
  • Large Granular Lymphocytosis
  • Leukemia, NK-LGL
  • Leukemia, Natural Killer Cell Large Granular Lymphocytic
  • Leukemia, T-Cell Large Granular Lymphocytic
  • Leukemia, T-LGL
  • NK-Cell Large Granular Lymphocytic Leukemia
  • NK-LGL Leukemia
  • Natural Killer Cell Large Granular Lymphocytic Leukemia
  • T-Cell Large Granular Lymphocyte Leukemia
  • T-Cell Large Granular Lymphocytic Leukemia
  • T-LGL Leukemia
  • Granular Lymphocytoses, Large
  • Granular Lymphocytosis, Large
  • Large Granular Lymphocytoses
  • Leukemia, NK LGL
  • Leukemia, T Cell Large Granular Lymphocytic
  • Leukemia, T LGL
  • Leukemias, NK-LGL
  • Leukemias, T-LGL
  • Lymphocytoses, Large Granular
  • Lymphocytosis, Large Granular
  • NK Cell Large Granular Lymphocytic Leukemia
  • NK LGL Leukemia
  • NK-LGL Leukemias
  • T Cell Large Granular Lymphocyte Leukemia
  • T Cell Large Granular Lymphocytic Leukemia
  • T LGL Leukemia
  • T-LGL Leukemias

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2008; use LEUKEMIA, LYMPHOCYTIC 1997-2007

MeSH Record

Previous Indexing

  • Leukemia, Lymphocytic (1987-2007)

MeSH Hierarchy

Tree Numbers

  1. C04w.557.337w.428w.580w.049w
  2. C15.378w.508w.428w.580w.049w
  3. C15.604w.515w.560w.575w.049w
  4. C20w.683w.515w.528w.582w.049w

AMA Style

References

  1. National Library of Medicine. Large Granular Lymphocytic Leukemia. Medical Subject Headings (MeSH). 2026. Unique ID D054066. http://id.nlm.nih.gov/mesh/2026/D054066
  2. Large Granular Lymphocytic Leukemia. In: Wikipedia. https://en.wikipedia.org/wiki/Large_granular_lymphocytic_leukemia
  3. Large Granular Lymphocytic Leukemia. In: Wikidata. https://www.wikidata.org/wiki/Q6489151