Chemicals and Drugs

Lapatinib

A quinazoline derivative that inhibits EPIDERMAL GROWTH FACTOR RECEPTOR and HER2 (ERB-B2 RECEPTOR TYROSINE KINASES) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress HER2.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A quinazoline derivative that inhibits EPIDERMAL GROWTH FACTOR RECEPTOR and HER2 (ERB-B2 RECEPTOR TYROSINE KINASES) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress HER2.

Chemical Identity

Chemical Information

Molecular Formula
C29H26ClFN4O4S
Molecular Weight
581.1 g/mol
CAS Registry No.
231277-92-2
IUPAC Name
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
InChIKey
BCFGMOOMADDAQU-UHFFFAOYSA-N
SMILES
CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
MeSH Unique ID
D000077341
Source
PubChem CID 208908

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • N-(3-chloro-4-(((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-methylsulfonyl)ethyl)amino)methyl) -2-furyl)-4-quinazolinamine
  • GW 282974X
  • GW 572016
  • GW-282974X
  • GW-572016
  • GW282974X
  • GW572016
  • Lapatinib Ditosylate
  • Tykerb

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (2004)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.786.516w

AMA Style

References

  1. National Library of Medicine. Lapatinib. Medical Subject Headings (MeSH). 2026. Unique ID D000077341. http://id.nlm.nih.gov/mesh/2026/D000077341
  2. Lapatinib. In: Wikipedia. https://en.wikipedia.org/wiki/Lapatinib
  3. Lapatinib. In: Wikidata. https://www.wikidata.org/wiki/Q420323
  4. Lapatinib. In: PubChem Compound. CID 208908. https://pubchem.ncbi.nlm.nih.gov/compound/208908