Diseases

Kleine-Levin Syndrome

A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

17 entry terms
  • Hypersomnia, Periodic
  • Kleine-Levin Hibernation Syndrome
  • Kleine-Levin-Critchley Syndrome
  • Hibernation Syndrome, Kleine-Levin
  • Kleine Levin Critchley Syndrome
  • Kleine Levin Hibernation Syndrome
  • Kleine Levin Syndrome
  • Periodic Hypersomnia
  • Periodic Hypersomnias
  • Syndrome, Kleine-Levin
  • Syndrome, Kleine-Levin Hibernation
  • Syndrome, Kleine-Levin-Critchley
  • Familial Hibernation (Kleine-Levin) Syndrome
  • Familial Kleine-Levin Syndrome
  • Familial Kleine Levin Syndrome
  • Kleine-Levin Syndrome, Familial
  • Syndrome, Familial Kleine-Levin

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

94

MeSH Record

Previous Indexing

  • Eating Disorders (1966-1976)
  • Hunger (1966-1971)
  • Hyperphagia (1981-1993)
  • Hypersomnia (1975-1993)
  • Sleep Disorders (1966-1979)

MeSH Hierarchy

Tree Numbers

  1. C10w.886.425w.800.200w.500w
  2. F03w.870.400w.800.200w.500w

AMA Style

References

  1. National Library of Medicine. Kleine-Levin Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D017593. http://id.nlm.nih.gov/mesh/2026/D017593
  2. Kleine-Levin Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Kleine%E2%80%93Levin_syndrome
  3. Kleine-Levin Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q613809