Chemicals and Drugs

Kelch-Like ECH-Associated Protein 1

An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • KEAP-1 Protein
  • KEAP1 Protein
  • KEAP 1 Protein
  • Kelch Like ECH Associated Protein 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Adaptor Proteins, Signal Transducing (2005-2016)
  • Carrier Proteins (1999-2016)
  • Intracellular Signaling Peptides and Proteins (2004-2016)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.306
  2. D12.776w.157w.057w.067
  3. D12.776w.476.024w.387

AMA Style

References

  1. National Library of Medicine. Kelch-Like ECH-Associated Protein 1. Medical Subject Headings (MeSH). 2026. Unique ID D000072019. http://id.nlm.nih.gov/mesh/2026/D000072019
  2. Kelch-Like ECH-Associated Protein 1. In: Wikidata. https://www.wikidata.org/wiki/Q24739073