Chemicals and Drugs

Kainic Acid

(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.

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Drug Class

Pharmacological Action

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Synonyms

4 entry terms
  • Digenic Acid
  • Acid, Digenic
  • Acid, Kainic
  • Kainate

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Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

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Indexing Annotation

an antinematodal agent & excitatory amino acid agonist

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History Note

86(78); was see under PYRROLIDINES 1978-85

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Previous Indexing

  • Pyrrolidines (1966-1977)

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AMA Style

References

  1. National Library of Medicine. Kainic Acid. Medical Subject Headings (MeSH). 2026. Unique ID D007608. http://id.nlm.nih.gov/mesh/2026/D007608
  2. Kainic Acid. In: Wikipedia. https://en.wikipedia.org/wiki/Kainic_acid
  3. Kainic Acid. In: Wikidata. https://www.wikidata.org/wiki/Q390239