Structured Summary
Abstract
A microtubule-associated protein consisting of four ANKYRIN REPEATS and a C-terminal FERM DOMAIN. It links the CYTOSKELETON to CELL JUNCTIONS via integrin cytoplasmic domain-associated protein-1 and plays an important role in regulating cell proliferation and integrity of endothelial cell junctions. It is also involved in REACTIVE OXYGEN SPECIES metabolism. Mutations in the KRIT1 gene are associated with type I CEREBRAL CAVERNOUS MALFORMATIONS.
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Synonyms
2 entry terms
- Cerebral Cavernous Malformations 1 Protein
- Krev Interaction Trapped Protein 1
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Microtubule-Associated Proteins (1997-2017)
- Proto-Oncogene Proteins (1997-2017)
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AMA Style
References
- National Library of Medicine. KRIT1 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000075927. http://id.nlm.nih.gov/mesh/2026/D000075927
- KRIT1 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21117068