Chemicals and Drugs

Jagged-1 Protein

A serrate-jagged protein that functions as a ligand for NOTCH RECEPTORS. It may regulate CELL DIFFERENTIATION in HEMATOPOIESIS and PHYSIOLOGIC ANGIOGENESIS. Mutations in the Jagged-1 gene are associated with ALAGILLE SYNDROME 1.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A serrate-jagged protein that functions as a ligand for NOTCH RECEPTORS. It may regulate CELL DIFFERENTIATION in HEMATOPOIESIS and PHYSIOLOGIC ANGIOGENESIS. Mutations in the Jagged-1 gene are associated with ALAGILLE SYNDROME 1.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

10 entry terms
  • Alagille Syndrome Protein
  • CD339 Antigen
  • Jagged-1
  • Jagged1 Protein
  • Serrate-1 Protein
  • Serrate1 Protein
  • Antigen, CD339
  • Jagged 1
  • Jagged 1 Protein
  • Serrate 1 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017 (1991)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.930.500
  2. D12.776w.157w.125w.797.500
  3. D12.776w.543w.800.500
  4. D23.529.930.500

AMA Style

References

  1. National Library of Medicine. Jagged-1 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000072100. http://id.nlm.nih.gov/mesh/2026/D000072100
  2. Jagged-1 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q3780451