Chemicals and Drugs

Ivabradine

A benzazepine derivative and selective HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS inhibitor that lowers the heart rate. It is used in the treatment of CHRONIC STABLE ANGINA in patients unable to take BETA-ADRENERGIC BLOCKERS, and in the treatment of HEART FAILURE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A benzazepine derivative and selective HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS inhibitor that lowers the heart rate. It is used in the treatment of CHRONIC STABLE ANGINA in patients unable to take BETA-ADRENERGIC BLOCKERS, and in the treatment of HEART FAILURE.

Chemical Identity

Chemical Information

Molecular Formula
C27H36N2O5
Molecular Weight
468.6 g/mol
CAS Registry No.
155974-00-8
IUPAC Name
3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one
InChIKey
ACRHBAYQBXXRTO-OAQYLSRUSA-N
SMILES
CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)C[C@H]3CC4=CC(=C(C=C34)OC)OC
MeSH Unique ID
D000077550
Source
PubChem CID 132999

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • 7,8-Dimethoxy-3-(3-(((4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one
  • Corlanor
  • S 16257
  • S 16257-2
  • S 16260-2
  • S-16257
  • S-16257-2
  • S-16260-2
  • S 16257 2
  • S 162572
  • S 16260 2
  • S 162602
  • S16257
  • S162572
  • S162602

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1994)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.079.801w

AMA Style

References

  1. National Library of Medicine. Ivabradine. Medical Subject Headings (MeSH). 2026. Unique ID D000077550. http://id.nlm.nih.gov/mesh/2026/D000077550
  2. Ivabradine. In: Wikipedia. https://en.wikipedia.org/wiki/Ivabradine
  3. Ivabradine. In: Wikidata. https://www.wikidata.org/wiki/Q425729
  4. Ivabradine. In: PubChem Compound. CID 132999. https://pubchem.ncbi.nlm.nih.gov/compound/132999