Chemicals and Drugs

Isotretinoin

A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.

Chemical Identity

Chemical Information

Molecular Formula
C20H28O2
Molecular Weight
300.4 g/mol
CAS Registry No.
4759-48-2
IUPAC Name
(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
InChIKey
SHGAZHPCJJPHSC-XFYACQKRSA-N
SMILES
CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\C(=O)O)/C)/C
MeSH Unique ID
D015474
Source
PubChem CID 5282379

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • 13-cis-Retinoic Acid
  • 13 cis Retinoic Acid
  • Accutane
  • Isotretinoin Zinc Salt, 13-cis-Isomer
  • Ro 4-3780
  • Roaccutane
  • Isotretinoin Zinc Salt, 13 cis Isomer
  • Ro 4 3780
  • Ro 43780

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • Dermatologic Agents (1975-1988)
  • Keratolytic Agents (1975-1988)
  • Tretinoin (1975-1988)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.326.271w.665w.202w.495w.325w
  2. D02w.455w.426w.392.368w.367.379.249w.700w.325w
  3. D02w.455w.849w.131w.495w.325w
  4. D23.767w.261w.700w.325w

AMA Style

References

  1. National Library of Medicine. Isotretinoin. Medical Subject Headings (MeSH). 2026. Unique ID D015474. http://id.nlm.nih.gov/mesh/2026/D015474
  2. Isotretinoin. In: Wikipedia. https://en.wikipedia.org/wiki/Isotretinoin
  3. Isotretinoin. In: Wikidata. https://www.wikidata.org/wiki/Q287029
  4. Isotretinoin. In: PubChem Compound. CID 5282379. https://pubchem.ncbi.nlm.nih.gov/compound/5282379