Chemicals and Drugs

Isophane Insulin

An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.

MeSH Record

Classification

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • Insulin, Isophane
  • Insulin, NPH
  • Isophane Insulin, Regular
  • NPH Insulin
  • Neutral Protamine Hagedorn Insulin
  • Protamine Hagedorn Insulin
  • Hagedorn Insulin, Protamine
  • Regular Isophane Insulin
  • Insulin, Protamine Zinc
  • Protamine Zinc Insulin
  • Zinc Insulin, Protamine

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2009 (1963); for INSULIN, PROTAMINE ZINC use INSULIN, LONG-ACTING 1966-2011

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References

  1. National Library of Medicine. Isophane Insulin. Medical Subject Headings (MeSH). 2026. Unique ID D007336. http://id.nlm.nih.gov/mesh/2026/D007336
  2. Isophane Insulin. In: Wikipedia. https://en.wikipedia.org/wiki/NPH_insulin
  3. Isophane Insulin. In: Wikidata. https://www.wikidata.org/wiki/Q1929845