Structured Summary
Abstract
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
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Synonyms
7 entry terms
- Isocitrate Dehydrogenase (NAD+)
- NAD Isocitrate Dehydrogenase
- Dehydrogenase, Isocitrate
- Dehydrogenase, NAD Isocitrate
- Isocitrate Dehydrogenase, NAD
- Isocitrate Dehydrogenase-I
- Isocitrate Dehydrogenase I
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
65(63)
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References
- National Library of Medicine. Isocitrate Dehydrogenase. Medical Subject Headings (MeSH). 2026. Unique ID D007521. http://id.nlm.nih.gov/mesh/2026/D007521
- Isocitrate Dehydrogenase. In: Wikipedia. https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase
- Isocitrate Dehydrogenase. In: Wikidata. https://www.wikidata.org/wiki/Q261968