Anatomy

Isochromosomes

Metacentric chromosomes produced during MEIOSIS or MITOSIS when the CENTROMERE splits transversely instead of longitudinally. The chromosomes produced by this abnormal division are one chromosome having the two long arms of the original chromosome, but no short arms, and the other chromosome consisting of the two short arms and no long arms. Each of these isochromosomes constitutes a simultaneous duplication and deletion.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Metacentric chromosomes produced during MEIOSIS or MITOSIS when the CENTROMERE splits transversely instead of longitudinally. The chromosomes produced by this abnormal division are one chromosome having the two long arms of the original chromosome, but no short arms, and the other chromosome consisting of the two short arms and no long arms. Each of these isochromosomes constitutes a simultaneous duplication and deletion.

MeSH Record

Classification

Broader headings

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Synonyms

1 entry terms
  • Isochromosome

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

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Indexing Annotation

note category

MeSH Record

History Note

95

MeSH Record

Previous Indexing

  • Chromosome Aberrations (1966-1994)
  • specific chromosome (1966-1994)

MeSH Hierarchy

Tree Numbers

  1. A11w.284w.187w.570w
  2. C23.550.210w.430w
  3. G05.360w.162w.570w
  4. G05.365w.590w.175w.430w

AMA Style

References

  1. National Library of Medicine. Isochromosomes. Medical Subject Headings (MeSH). 2026. Unique ID D018404. http://id.nlm.nih.gov/mesh/2026/D018404
  2. Isochromosomes. In: Wikipedia. https://en.wikipedia.org/wiki/Isochromosome
  3. Isochromosomes. In: Wikidata. https://www.wikidata.org/wiki/Q900950