Structured Summary
Abstract
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
MeSH Record
Classification
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MeSH Record
Synonyms
10 entry terms
- ACO1 Protein
- Aconitase 1, Soluble
- Ferritin Repressor Protein
- IRE-BP1
- IRP-1 Protein
- IRP1 Protein
- IRE BP1
- IRP 1 Protein
- Repressor Protein, Ferritin
- Soluble Aconitase 1
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2003; for FERRITIN REPRESSOR PROTEIN use IRON-REGULATORY PROTEINS (NM) 1991-2002, for IRE-BP1, IRON REGULATORY PROTEIN 1, IRP-1 PROTEIN & IRP1 PROTEIN use IRON-REGULATORY PROTEINS (NM) 1995-2002
MeSH Record
Previous Indexing
- Iron-Sulfur Proteins (1995-2002)
- Ribonucleoproteins (1995-2002)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Iron Regulatory Protein 1. Medical Subject Headings (MeSH). 2026. Unique ID D035941. http://id.nlm.nih.gov/mesh/2026/D035941
- Iron Regulatory Protein 1. In: Wikidata. https://www.wikidata.org/wiki/Q24780747