Structured Summary
Abstract
A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
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Classification
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Drug Class
Pharmacological Action
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See Also
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Synonyms
10 entry terms
- Cytotoxic Lymphocyte Maturation Factor
- IL 12
- IL-12
- IL-12 p70
- IL12
- Interleukin 12
- Interleukin-12 p70
- Natural Killer Cell Stimulatory Factor
- Interleukin 12 p70
- Edodekin Alfa
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
1995 (1991)
MeSH Record
Previous Indexing
- Interleukins (1991-1994)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Interleukin-12. Medical Subject Headings (MeSH). 2026. Unique ID D018664. http://id.nlm.nih.gov/mesh/2026/D018664
- Interleukin-12. In: Wikipedia. https://en.wikipedia.org/wiki/Interleukin_12
- Interleukin-12. In: Wikidata. https://www.wikidata.org/wiki/Q2409681