Chemicals and Drugs

Interferon alpha-beta Receptor

A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.

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Classification

Broader headings

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MeSH Record

Synonyms

39 entry terms
  • IFN-alphaR
  • IFN-alphabetaR
  • Interferon alpha Receptor
  • Interferon alpha Receptors
  • Interferon alphabeta Receptors
  • Receptor, Interferon alpha
  • Receptor, Interferon alpha-beta
  • Type I Interferon Receptor
  • IFN alphabetaR
  • Interferon alpha beta Receptor
  • Receptor, Interferon alpha beta
  • Receptors, Interferon alpha
  • Receptors, Interferon alphabeta
  • alpha Receptor, Interferon
  • alpha Receptors, Interferon
  • IFNAR1 Subunit, Interferon alpha-beta Receptor
  • IFNAR2 Subunit, Interferon alpha-beta Receptor
  • IFNAR2.1 Subunit, Interferon alpha-beta Receptor
  • IFNAR2.2 Subunit, Interferon alpha-beta Receptor
  • Interferon alpha-beta Receptor Chain 1
  • Interferon alpha-beta Receptor Chain 2
  • Interferon alpha-beta Receptor IFNAR1 Subunit
  • Interferon alpha-beta Receptor IFNAR2 Subunit
  • Interferon alpha-beta Receptor-1
  • Interferon alpha-beta Receptor-2
  • IFNAR1 Subunit, Interferon alpha beta Receptor
  • IFNAR2 Subunit, Interferon alpha beta Receptor
  • IFNAR2.1 Subunit, Interferon alpha beta Receptor
  • IFNAR2.2 Subunit, Interferon alpha beta Receptor
  • Interferon alpha beta Receptor 1
  • Interferon alpha beta Receptor 2
  • Interferon alpha beta Receptor Chain 1
  • Interferon alpha beta Receptor Chain 2
  • Interferon alpha beta Receptor IFNAR1 Subunit
  • Interferon alpha beta Receptor IFNAR2 Subunit
  • Receptor-1, Interferon alpha-beta
  • Receptor-2, Interferon alpha-beta
  • alpha-beta Receptor-1, Interferon
  • alpha-beta Receptor-2, Interferon

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2007(1993)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.705w.852w.400.500w

AMA Style

References

  1. National Library of Medicine. Interferon alpha-beta Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D053633. http://id.nlm.nih.gov/mesh/2026/D053633
  2. Interferon alpha-beta Receptor. In: Wikipedia. https://en.wikipedia.org/wiki/Interferon-alpha/beta_receptor
  3. Interferon alpha-beta Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q6046426