Chemicals and Drugs

Interferon-alpha

One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

36 entry terms
  • Interferon Alfa
  • Interferon, Leukocyte
  • Interferon, Lymphoblast
  • Interferon, Lymphoblastoid
  • Interferon, alpha
  • alpha-Interferon
  • Interferon alpha
  • Leukocyte Interferon
  • Lymphoblast Interferon
  • Lymphoblastoid Interferon
  • alpha Interferon
  • IFN-alpha D
  • IFN-alpha5
  • Interferon alpha-1
  • Interferon alpha-17
  • Interferon alpha-4
  • Interferon alpha-5
  • Interferon alpha-7
  • Interferon alpha-88
  • Interferon alpha-J
  • Interferon alpha-T
  • Interferon alpha4
  • Interferon alpha5
  • LeIF I
  • LeIF J
  • Leif D
  • IFN alpha D
  • IFN alpha5
  • Interferon alpha 1
  • Interferon alpha 17
  • Interferon alpha 4
  • Interferon alpha 5
  • Interferon alpha 7
  • Interferon alpha 88
  • Interferon alpha J
  • Interferon alpha T

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1992; for INTERFERON, LYMPHOBLAST and INTERFERON, LEUKOCYTE use INTERFERON TYPE I 1989-1991

MeSH Record

Previous Indexing

  • Interferon Type I (1983-1991)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.374w.440w.890w.250
  2. D12.776w.467.374w.440w.890w.250
  3. D23.529.374w.440w.890w.250

AMA Style

References

  1. National Library of Medicine. Interferon-alpha. Medical Subject Headings (MeSH). 2026. Unique ID D016898. http://id.nlm.nih.gov/mesh/2026/D016898
  2. Interferon-alpha. In: Wikidata. https://www.wikidata.org/wiki/Q20817235