Chemicals and Drugs

Integrin alphaVbeta3

An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

11 entry terms
  • Integrin alpha-v beta-3
  • Receptors, alpha-v beta-3 Integrin
  • Vitronectin Receptor
  • alpha-v beta-3 Integrin Receptors
  • Integrin alpha v beta 3
  • Receptor, Vitronectin
  • Receptors, alpha v beta 3 Integrin
  • alpha v beta 3 Integrin Receptors
  • alpha-v beta-3, Integrin
  • alphaVbeta3, Integrin
  • beta-3, Integrin alpha-v

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

Indexing Annotation

do not confuse entry term VITRONECTIN RECEPTOR with VITRONECTIN RECEPTORS

MeSH Record

History Note

2003; use RECEPTORS, VITRONECTIN 1996-2002

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.625w.439w
  2. D12.776w.395w.550w.625w.439w
  3. D12.776w.543w.550w.625w.439w
  4. D12.776w.543w.750w.705w.408w.460.870.500w
  5. D12.776w.543w.750w.705w.675w.541w

AMA Style

References

  1. National Library of Medicine. Integrin alphaVbeta3. Medical Subject Headings (MeSH). 2026. Unique ID D039302. http://id.nlm.nih.gov/mesh/2026/D039302
  2. Integrin alphaVbeta3. In: Wikipedia. https://en.wikipedia.org/wiki/Alpha-v_beta-3
  3. Integrin alphaVbeta3. In: Wikidata. https://www.wikidata.org/wiki/Q50254584