Chemicals and Drugs

Integrin alpha6beta1

A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.

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Classification

Broader headings

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See Also

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Synonyms

17 entry terms
  • CD49f-CD29
  • Integrin alpha(6)beta(1)
  • Platelet Glycoprotein I'c-IIa
  • VLA-6
  • alpha 6 beta 1 Integrin
  • alpha6beta1 Integrin
  • CD49f CD29
  • Glycoprotein I'c-IIa, Platelet
  • I'c-IIa, Platelet Glycoprotein
  • Integrin, alpha6beta1
  • Platelet Glycoprotein I'c IIa
  • VLA 6
  • alpha6beta1, Integrin
  • Integrin alpha6Abeta1
  • Integrin alpha6Bbeta1
  • alpha6Abeta1, Integrin
  • alpha6Bbeta1, Integrin

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2003; use INTEGRIN ALPHA6BETA1 (NM) 1992-2002

MeSH Record

Previous Indexing

  • Integrins (1992-2002)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.625w.419
  2. D12.776w.395w.550w.625w.419
  3. D12.776w.543w.550w.625w.419
  4. D12.776w.543w.750w.705w.408w.850.674
  5. D12.776w.543w.750w.705w.675w.514
  6. D12.776w.543w.750w.705w.876.500

AMA Style

References

  1. National Library of Medicine. Integrin alpha6beta1. Medical Subject Headings (MeSH). 2026. Unique ID D039121. http://id.nlm.nih.gov/mesh/2026/D039121
  2. Integrin alpha6beta1. In: Wikidata. https://www.wikidata.org/wiki/Q50257506