Chemicals and Drugs

Integrin alpha2beta1

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

13 entry terms
  • CD49b-CD29
  • Glycoprotein Ia-IIa
  • Platelet Membrane Glycoprotein Heterodimer Ia-IIa
  • VLA-2
  • Very Late Antigen-2
  • alpha2beta1Integrin
  • CD49b CD29
  • Glycoprotein Ia IIa
  • Late Antigen-2, Very
  • Platelet Membrane Glycoprotein Heterodimer Ia IIa
  • VLA 2
  • Very Late Antigen 2
  • alpha2beta1, Integrin

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2003; for VLA-2 use COLLAGEN RECEPTORS (NM) 1991-2002; for PLATELET MEMBRANE GLYCOPROTEIN HETERODIMER IA-IIA use COLLAGEN RECEPTORS (NM) 1992-2000; for INTEGRIN ALPHA2BETA1 & CD49B-CD29 use COLLAGEN RECEPTORS (NM) 1994-2002; for ALPHA2BETA1INTEGRIN use COLLAGEN RECEPTORS (NM) 2001-2002

MeSH Record

Previous Indexing

  • Collagen Receptors (1991-2002)
  • Integrins (1994-2002)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.625w.298
  2. D12.776w.395w.550w.625w.298
  3. D12.776w.543w.550w.625w.298
  4. D12.776w.543w.750w.685w.200
  5. D12.776w.543w.750w.705w.408w.530.249
  6. D12.776w.543w.750w.705w.408w.850.199
  7. D12.776w.543w.750w.705w.675w.352
  8. D12.776w.543w.750w.705w.876.280

AMA Style

References

  1. National Library of Medicine. Integrin alpha2beta1. Medical Subject Headings (MeSH). 2026. Unique ID D038982. http://id.nlm.nih.gov/mesh/2026/D038982
  2. Integrin alpha2beta1. In: Wikidata. https://www.wikidata.org/wiki/Q50254637