Chemicals and Drugs

Integrin alpha1beta1

Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

6 entry terms
  • CD49a-CD29
  • Integrin alpha(1)beta(1)
  • VLA-1
  • alpha1beta1 Integrin
  • Integrin, alpha1beta1
  • alpha1beta1, Integrin

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2003; use INTEGRIN ALPHA1BETA1 (NM) 1994-2002

MeSH Record

Previous Indexing

  • Integrins (1994-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.543w.750w.685w.100
  2. D12.776w.543w.750w.705w.408w.850.099
  3. D12.776w.543w.750w.705w.876.249

AMA Style

References

  1. National Library of Medicine. Integrin alpha1beta1. Medical Subject Headings (MeSH). 2026. Unique ID D039222. http://id.nlm.nih.gov/mesh/2026/D039222
  2. Integrin alpha1beta1. In: Wikidata. https://www.wikidata.org/wiki/Q50254094