Phenomena and Processes

Integrated Stress Response

A signaling pathway that enables cells to adapt to various stressors by modulating protein synthesis. It is initiated by the activation of specific PROTEIN KINASES (e.g., PERK, GCN2, PKR, and HRI) in response to distinct stress signals, including amino acid deprivation, VIRAL INFECTIONS, and OXIDATIVE STRESS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A signaling pathway that enables cells to adapt to various stressors by modulating protein synthesis. It is initiated by the activation of specific PROTEIN KINASES (e.g., PERK, GCN2, PKR, and HRI) in response to distinct stress signals, including amino acid deprivation, VIRAL INFECTIONS, and OXIDATIVE STRESS.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

1 entry terms
  • Integrated Stress Response (ISR)

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2026

MeSH Record

Previous Indexing

  • PI scattered

MeSH Hierarchy

Tree Number

  1. G07.775w.563w

AMA Style

References

  1. National Library of Medicine. Integrated Stress Response. Medical Subject Headings (MeSH). 2026. Unique ID D000099121. http://id.nlm.nih.gov/mesh/2026/D000099121
  2. Integrated Stress Response. In: Wikipedia. https://en.wikipedia.org/wiki/Integrated_stress_response
  3. Integrated Stress Response. In: Wikidata. https://www.wikidata.org/wiki/Q6043166