Phenomena and Processes

Immunoreceptor Tyrosine-Based Inhibition Motif

A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.

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Broader headings

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MeSH Record

Synonyms

5 entry terms
  • Immune Receptor Tyrosine-Based Inhibition Motif
  • Immuno-Receptor Tyrosine-Based Inhibition Motif
  • Immune Receptor Tyrosine Based Inhibition Motif
  • Immuno Receptor Tyrosine Based Inhibition Motif
  • Immunoreceptor Tyrosine Based Inhibition Motif

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2013

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.500.480w

AMA Style

References

  1. National Library of Medicine. Immunoreceptor Tyrosine-Based Inhibition Motif. Medical Subject Headings (MeSH). 2026. Unique ID D061626. http://id.nlm.nih.gov/mesh/2026/D061626
  2. Immunoreceptor Tyrosine-Based Inhibition Motif. In: Wikipedia. https://en.wikipedia.org/wiki/Immunoreceptor_tyrosine-based_inhibitory_motif
  3. Immunoreceptor Tyrosine-Based Inhibition Motif. In: Wikidata. https://www.wikidata.org/wiki/Q12745555