Diseases

Immunoproliferative Small Intestinal Disease

A condition that is caused by HYPERPLASIA of LYMPHOCYTES in the small intestine (INTESTINE, SMALL) and the mesenteric LYMPH NODES. These lymphocytes produce an anomalous alpha heavy chain protein. Generally, these IPSID patients have either concurrent LYMPHOMA or develop lymphoma within a few years. The disease was first described in the Mediterranean region and is characterized by malabsorption; WEIGHT LOSS; DIARRHEA; and STEATORRHEA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A condition that is caused by HYPERPLASIA of LYMPHOCYTES in the small intestine (INTESTINE, SMALL) and the mesenteric LYMPH NODES. These lymphocytes produce an anomalous alpha heavy chain protein. Generally, these IPSID patients have either concurrent LYMPHOMA or develop lymphoma within a few years. The disease was first described in the Mediterranean region and is characterized by malabsorption; WEIGHT LOSS; DIARRHEA; and STEATORRHEA.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

9 entry terms
  • Heavy Chain Disease, IgA Type
  • IPSID
  • Lymphoma, Mediterranean
  • alpha-Chain Disease
  • Disease, alpha-Chain
  • Diseases, alpha-Chain
  • Mediterranean Lymphoma
  • alpha Chain Disease
  • alpha-Chain Diseases

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

87

MeSH Record

Previous Indexing

  • Heavy Chain Disease (1966-1986)
  • Intestinal Neoplasms (1966-1986)
  • Lymphoma (1966-1986)

MeSH Hierarchy

Tree Numbers

  1. C04w.557.386w.390
  2. C06w.301.371.411w.512
  3. C06w.405w.249.411w.512
  4. C06w.405w.469w.491w.505
  5. C15.378w.147.780w.490w.512
  6. C15.604w.515w.435w.512
  7. C20w.683w.515w.512
  8. C20w.683w.780w.490w.512

AMA Style

References

  1. National Library of Medicine. Immunoproliferative Small Intestinal Disease. Medical Subject Headings (MeSH). 2026. Unique ID D007161. http://id.nlm.nih.gov/mesh/2026/D007161
  2. Immunoproliferative Small Intestinal Disease. In: Wikidata. https://www.wikidata.org/wiki/Q1916505