Diseases

Immunoglobulin Light-chain Amyloidosis

A nonproliferative disorder of PLASMA CELLS characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nonproliferative disorder of PLASMA CELLS characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

17 entry terms
  • AL Amyloidosis
  • Amyloidosis, Immunoglobulin Light-chain
  • Amyloidosis, Primary
  • Monoclonal Immunoglobulin Deposition Disease
  • Primary Amyloidosis
  • Primary Systemic Amyloidosis
  • AL Amyloidoses
  • Amyloidoses, Primary
  • Amyloidoses, Primary Systemic
  • Amyloidosis, Immunoglobulin Light chain
  • Amyloidosis, Primary Systemic
  • Immunoglobulin Light chain Amyloidosis
  • Immunoglobulin Light-chain Amyloidoses
  • Primary Amyloidoses
  • Primary Systemic Amyloidoses
  • Systemic Amyloidoses, Primary
  • Systemic Amyloidosis, Primary

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2018(2010)

MeSH Hierarchy

Tree Numbers

  1. C04w.557.595.250w
  2. C18.452w.845.500w.550w
  3. C20w.683w.515w.507w
  4. C20w.683w.780w.565w

AMA Style

References

  1. National Library of Medicine. Immunoglobulin Light-chain Amyloidosis. Medical Subject Headings (MeSH). 2026. Unique ID D000075363. http://id.nlm.nih.gov/mesh/2026/D000075363
  2. Immunoglobulin Light-chain Amyloidosis. In: Wikipedia. https://en.wikipedia.org/wiki/AL_amyloidosis
  3. Immunoglobulin Light-chain Amyloidosis. In: Wikidata. https://www.wikidata.org/wiki/Q4652470