Chemicals and Drugs

Immunoglobulin Fc Fragments

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

MeSH Record

Classification

Broader headings

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

16 entry terms
  • Fc Fragment
  • Fc Fragments
  • Fc Immunoglobulin
  • Fc Immunoglobulins
  • Ig Fc Fragments
  • Immunoglobulin Fc Fragment
  • Immunoglobulins, Fc
  • Immunoglobulins, Fc Fragment
  • Fc Fragment Immunoglobulins
  • Fc Fragment, Immunoglobulin
  • Fc Fragments, Ig
  • Fc Fragments, Immunoglobulin
  • Fragment Immunoglobulins, Fc
  • Fragment, Fc
  • Fragments, Ig Fc
  • Immunoglobulin, Fc

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006 (1973)

MeSH Record

Previous Indexing

  • Immunoglobulins (1970-1972)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.541.500.697
  2. D12.776w.124w.486.485.538.500
  3. D12.776w.124w.486.485.680.697
  4. D12.776w.124w.790.651.538.500
  5. D12.776w.124w.790.651.680.660
  6. D12.776w.377w.715.548.538.500
  7. D12.776w.377w.715.548.680.660

AMA Style

References

  1. National Library of Medicine. Immunoglobulin Fc Fragments. Medical Subject Headings (MeSH). 2026. Unique ID D007141. http://id.nlm.nih.gov/mesh/2026/D007141
  2. Immunoglobulin Fc Fragments. In: Wikidata. https://www.wikidata.org/wiki/Q77201006