Chemicals and Drugs

Hypoxia-Inducible Factor-Proline Dioxygenases

Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent enzymes that play an important role in mediating cellular adaptive responses to HYPOXIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent enzymes that play an important role in mediating cellular adaptive responses to HYPOXIA.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

22 entry terms
  • HIF Prolyl-4-Hydroxylase
  • HIF Prolyl-4-Hydroxylases
  • Hypoxia-Inducible Factor-Proline Dioxygenase
  • Dioxygenase, Hypoxia-Inducible Factor-Proline
  • Dioxygenases, Hypoxia-Inducible Factor-Proline
  • Factor-Proline Dioxygenase, Hypoxia-Inducible
  • Factor-Proline Dioxygenases, Hypoxia-Inducible
  • HIF Prolyl 4 Hydroxylase
  • HIF Prolyl 4 Hydroxylases
  • Hypoxia Inducible Factor Proline Dioxygenase
  • Hypoxia Inducible Factor Proline Dioxygenases
  • Prolyl-4-Hydroxylase, HIF
  • Prolyl-4-Hydroxylases, HIF
  • Egl Nine Homolog 1 Protein
  • Egl Nine Homolog 2 Protein
  • Egl Nine Homolog 3 Protein
  • Hypoxia-Inducible Factor Prolyl Hydroxylase 1
  • Hypoxia-Inducible Factor Prolyl Hydroxylase 2
  • Hypoxia-Inducible Factor Prolyl Hydroxylase 3
  • Hypoxia Inducible Factor Prolyl Hydroxylase 1
  • Hypoxia Inducible Factor Prolyl Hydroxylase 2
  • Hypoxia Inducible Factor Prolyl Hydroxylase 3

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2014

MeSH Record

Previous Indexing

  • Procollagen-Proline Dioxygenase (2004-2013)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.682w.690w.416w.617.500w
  2. D08.811w.682w.690w.708.694.500w

AMA Style

References

  1. National Library of Medicine. Hypoxia-Inducible Factor-Proline Dioxygenases. Medical Subject Headings (MeSH). 2026. Unique ID D064799. http://id.nlm.nih.gov/mesh/2026/D064799
  2. Hypoxia-Inducible Factor-Proline Dioxygenases. In: Wikipedia. https://en.wikipedia.org/wiki/Hypoxia-inducible_factor-proline_dioxygenase
  3. Hypoxia-Inducible Factor-Proline Dioxygenases. In: Wikidata. https://www.wikidata.org/wiki/Q3818007