Chemicals and Drugs

Hypoxanthine Phosphoribosyltransferase

An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

11 entry terms
  • Guanine Phosphoribosyltransferase
  • HGPRT
  • HPRT
  • HPRTase
  • Hypoxanthine-Guanine Phosphoribosyltransferase
  • IMP Pyrophosphorylase
  • Hypoxanthine Guanine Phosphoribosyltransferase
  • Phosphoribosyltransferase, Guanine
  • Phosphoribosyltransferase, Hypoxanthine
  • Phosphoribosyltransferase, Hypoxanthine-Guanine
  • Pyrophosphorylase, IMP

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/defic: consider also LESCH-NYHAN SYNDROME or GOUT

MeSH Record

History Note

75; GUANINE PHOSPHORIBOSYLTRANSFERASE was GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1978-91

MeSH Record

Previous Indexing

  • Pentosephosphates (1972-1974)
  • Pentosyltransferases (1972-1974)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.400w.725w.450w

AMA Style

References

  1. National Library of Medicine. Hypoxanthine Phosphoribosyltransferase. Medical Subject Headings (MeSH). 2026. Unique ID D007041. http://id.nlm.nih.gov/mesh/2026/D007041
  2. Hypoxanthine Phosphoribosyltransferase. In: Wikipedia. https://en.wikipedia.org/wiki/Hypoxanthine-guanine_phosphoribosyltransferase
  3. Hypoxanthine Phosphoribosyltransferase. In: Wikidata. https://www.wikidata.org/wiki/Q14864606