Diseases

Hyperhomocysteinemia

Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 μmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 μmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.

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Classification

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MeSH Record

Synonyms

1 entry terms
  • Hyperhomocysteinemias

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

1999

MeSH Record

Previous Indexing

  • Homocysteine/blood (1991-1998)

MeSH Hierarchy

Tree Numbers

MeSH Record

NLM Classification

QU 265.5.A5

AMA Style

References

  1. National Library of Medicine. Hyperhomocysteinemia. Medical Subject Headings (MeSH). 2026. Unique ID D020138. http://id.nlm.nih.gov/mesh/2026/D020138
  2. Hyperhomocysteinemia. In: Wikipedia. https://en.wikipedia.org/wiki/Hyperhomocysteinemia
  3. Hyperhomocysteinemia. In: Wikidata. https://www.wikidata.org/wiki/Q1093815