Chemicals and Drugs

Hydroxyzine

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

Chemical Identity

Chemical Information

Molecular Formula
C21H27ClN2O2
Molecular Weight
374.9 g/mol
CAS Registry No.
68-88-2
IUPAC Name
2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol
InChIKey
ZQDWXGKKHFNSQK-UHFFFAOYSA-N
SMILES
C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
MeSH Unique ID
D006919
Source
PubChem CID 3658

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • 2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol
  • Atarax
  • Durrax
  • Hydroxyzine Dihydrochloride
  • Hydroxyzine Hydrochloride
  • Hydroxyzine Pamoate
  • Orgatrax
  • Vistaril
  • Pamoate, Hydroxyzine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

  1. D03w.383.606w.515w

AMA Style

References

  1. National Library of Medicine. Hydroxyzine. Medical Subject Headings (MeSH). 2026. Unique ID D006919. http://id.nlm.nih.gov/mesh/2026/D006919
  2. Hydroxyzine. In: Wikipedia. https://en.wikipedia.org/wiki/Hydroxyzine
  3. Hydroxyzine. In: Wikidata. https://www.wikidata.org/wiki/Q421937
  4. Hydroxyzine. In: PubChem Compound. CID 3658. https://pubchem.ncbi.nlm.nih.gov/compound/3658