Chemicals and Drugs

Hydroxyurea

An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

Chemical Identity

Chemical Information

Molecular Formula
CH4N2O2
Molecular Weight
76.055 g/mol
CAS Registry No.
127-07-1
IUPAC Name
hydroxyurea
InChIKey
VSNHCAURESNICA-UHFFFAOYSA-N
SMILES
C(=O)(N)NO
MeSH Unique ID
D006918
Source
PubChem CID 3657

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • Hydroxycarbamid
  • Hydrea
  • Oncocarbide

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

68(67)

MeSH Record

Previous Indexing

  • Antineoplastic Agents (1966)
  • Urea (1966)

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. Hydroxyurea. Medical Subject Headings (MeSH). 2026. Unique ID D006918. http://id.nlm.nih.gov/mesh/2026/D006918
  2. Hydroxyurea. In: Wikipedia. https://en.wikipedia.org/wiki/Hydroxycarbamide
  3. Hydroxyurea. In: Wikidata. https://www.wikidata.org/wiki/Q212272
  4. Hydroxyurea. In: PubChem Compound. CID 3657. https://pubchem.ncbi.nlm.nih.gov/compound/3657