Diseases

Huntington Disease

A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

24 entry terms
  • Chorea, Chronic Progressive Hereditary (Huntington)
  • Chronic Progressive Hereditary Chorea (Huntington)
  • Huntington Chorea
  • Huntington Chronic Progressive Hereditary Chorea
  • Huntington's Chorea
  • Huntington's Disease
  • Progressive Chorea, Chronic Hereditary (Huntington)
  • Progressive Chorea, Hereditary, Chronic (Huntington)
  • Chorea, Huntington
  • Chorea, Huntington's
  • Akinetic-Rigid Variant of Huntington Disease
  • Huntington Disease, Akinetic-Rigid Variant
  • Huntington Disease, Juvenile
  • Huntington Disease, Juvenile-Onset
  • Huntington Disease, Late Onset
  • Juvenile Huntington Disease
  • Juvenile-Onset Huntington Disease
  • Late-Onset Huntington Disease
  • Akinetic Rigid Variant of Huntington Disease
  • Huntington Disease, Akinetic Rigid Variant
  • Huntington Disease, Juvenile Onset
  • Huntington Disease, Late-Onset
  • Juvenile Onset Huntington Disease
  • Late Onset Huntington Disease

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2000(1963)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.079w.545w
  2. C10w.228w.140w.380w.278w
  3. C10w.228w.662w.262w.249w.750w
  4. C10w.574w.500.497w
  5. C16w.320w.400.430w
  6. F03w.615w.250w.400w
  7. F03w.615w.400w.390w

MeSH Record

NLM Classification

WL 359.5

AMA Style

References

  1. National Library of Medicine. Huntington Disease. Medical Subject Headings (MeSH). 2026. Unique ID D006816. http://id.nlm.nih.gov/mesh/2026/D006816
  2. Huntington Disease. In: Wikipedia. https://en.wikipedia.org/wiki/Huntington%27s_disease
  3. Huntington Disease. In: Wikidata. https://www.wikidata.org/wiki/Q190564