Chemicals and Drugs

Huntingtin Protein

A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES. Huntingtin interacts with proteins involved in a variety of gene expression and cellular processes; it is also essential for embryonic development.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES. Huntingtin interacts with proteins involved in a variety of gene expression and cellular processes; it is also essential for embryonic development.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

2 entry terms
  • Huntington Disease Protein
  • IT15 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Nerve Tissue Proteins (2012-2016)
  • Nuclear Proteins (1994-2016)

MeSH Hierarchy

Tree Number

  1. D12.776w.441

AMA Style

References

  1. National Library of Medicine. Huntingtin Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000071058. http://id.nlm.nih.gov/mesh/2026/D000071058
  2. Huntingtin Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24779247