Structured Summary
Abstract
Semisynthetic derivative of harringtonine that acts as a protein synthesis inhibitor and induces APOPTOSIS in tumor cells. It is used in the treatment of MYELOID LEUKEMIA, CHRONIC.
Chemical Identity
Chemical Information
- Molecular Formula
- C29H39NO9
- Molecular Weight
- 545.6 g/mol
- IUPAC Name
- 1-O-(4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl) 4-O-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
- InChIKey
- HYFHYPWGAURHIV-UHFFFAOYSA-N
- SMILES
- CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O
- MeSH Unique ID
- D000077863
- Source
- PubChem CID 3628
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
Drug Class
Pharmacological Action
MeSH Record
Synonyms
6 entry terms
- Omacetaxine Mepesuccinate
- Ceflatonin
- Cephalotaxine
- Homoharringtonine (3(R))-isomer
- Omacetaxine
- Synribo
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1972)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Homoharringtonine. Medical Subject Headings (MeSH). 2026. Unique ID D000077863. http://id.nlm.nih.gov/mesh/2026/D000077863
- Homoharringtonine. In: Wikidata. https://www.wikidata.org/wiki/Q105035284
- Homoharringtonine. In: PubChem Compound. CID 3628. https://pubchem.ncbi.nlm.nih.gov/compound/3628