Structured Summary
Abstract
A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
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Synonyms
11 entry terms
- Homogentisate Dioxygenase
- Homogentisate Oxidase
- Homogentisate Oxygenase
- Homogentisic Acid Oxidase
- 1,2-Dioxygenase, Homogentisate
- Acid Oxidase, Homogentisic
- Dioxygenase, Homogentisate
- Homogentisate 1,2 Dioxygenase
- Oxidase, Homogentisate
- Oxidase, Homogentisic Acid
- Oxygenase, Homogentisate
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2006(1969)
MeSH Record
Previous Indexing
- Dioxygenases (1969-2005)
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AMA Style
References
- National Library of Medicine. Homogentisate 1,2-Dioxygenase. Medical Subject Headings (MeSH). 2026. Unique ID D050560. http://id.nlm.nih.gov/mesh/2026/D050560
- Homogentisate 1,2-Dioxygenase. In: Wikipedia. https://en.wikipedia.org/wiki/Homogentisate_1,2-dioxygenase
- Homogentisate 1,2-Dioxygenase. In: Wikidata. https://www.wikidata.org/wiki/Q24783466