Chemicals and Drugs

Histones

Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.

MeSH Record

Classification

Related Concepts

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MeSH Record

Synonyms

10 entry terms
  • Histone
  • Histone H1
  • Histone H1(s)
  • Histone H2a
  • Histone H2b
  • Histone H3
  • Histone H3.3
  • Histone H4
  • Histone H5
  • Histone H7

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

H1, H2a, H2b, H3, etc. go here

MeSH Hierarchy

Tree Numbers

MeSH Record

NLM Classification

QU 56

AMA Style

References

  1. National Library of Medicine. Histones. Medical Subject Headings (MeSH). 2026. Unique ID D006657. http://id.nlm.nih.gov/mesh/2026/D006657
  2. Histones. In: Wikipedia. https://en.wikipedia.org/wiki/Histone
  3. Histones. In: Wikidata. https://www.wikidata.org/wiki/Q36293