Structured Summary
Abstract
Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
MeSH Record
Classification
Related Concepts
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MeSH Record
Synonyms
9 entry terms
- HDAC Proteins
- Histone Deacetylase
- Deacetylase, Histone
- Deacetylases, Histone
- Class I Histone Deacetylases
- Class II Histone Deacetylases
- Histone Deacetylase Complexes
- Complexes, Histone Deacetylase
- Deacetylase Complexes, Histone
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2003; use AMIDOHYDROLASES 1975-1990
MeSH Record
Previous Indexing
- Acetic Acids (1971-1974)
- Amidohydrolases (1971-1974)
- Histones (1971-1974)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Histone Deacetylases. Medical Subject Headings (MeSH). 2026. Unique ID D006655. http://id.nlm.nih.gov/mesh/2026/D006655
- Histone Deacetylases. In: Wikipedia. https://en.wikipedia.org/wiki/Histone_deacetylase
- Histone Deacetylases. In: Wikidata. https://www.wikidata.org/wiki/Q174378